Methylsulfonylmethane (MSM)

SCIENTIFIC NAME(S): Methylsulfonylmethane, DMS02


Methylsulfonylmethane (MSM, or dimethylsulfone) is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains and in animals, including humans in at least trace amounts. MSM has also been found in such plants as Equisetem arvense, also known as horsetail. The biological role of MSM, if any, is not known. MSM is a metabolite of dimethyl sulfoxide or DMSO (see Dimethyl Sulfoxide). It is believed that some of the possible effects of DMSO could be attributed to MSM.


Literature searches on MSM provide mostly animal studies. MSM has been used as a food supplement.

Botany :- MSM is a natural chemical in green plants such as Equisetum arvense, certain algae, fruits, vegetables, and grains.It is also found in animals (eg, the adrenal cortex of cattle, human and bovine milk, and urine). MSM is naturally occurring in fresh foods; however, it is destroyed with even moderate food processing, such as heat or dehydration.

Uses of Methylsulfonylmethane(MSM)

MSM is said to alleviate gastrointestinal upset, musculoskeletal pain, arthritis, and allergies; to boost the immune system; and to possess antimicrobial effects although there are no known studies in humans to document these uses. Animal studies have also reported that joints affected by osteoarthritis ( OA ) have lower sulfur content

Side Effects of Methylsulfonylmethane (MSM)

  • Because no rigorously controlled studies of MSM usage of any length have been done in humans, long-term effects are not presently known.
  • Some people develop minor gastrointestinal discomfort, such as cramping and increased stool frequency with MSM use.
  • In rare cases, a skin rash may appear. Stop using MSM if this or any other allergic reaction occurs.


Some authorities report anecdotally that 250-500 mg per day has beneficial effects on a variety of health problems. 6 However, the only controlled trial using MSM used over 2000 mg per day to treat osteoarthritis . More research is needed before reliable recommendations for MSM supplementation can be made.


No important toxicities were noted in animal reports.

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