COMMON NAME(S): L-arginine

L-Arginine is a nonessential amino acid (the body can produce it on its own) and it is necessary for normal functioning of the pituitary gland. Males, whose seminal fluids contain up to 80% of this protein building block, especially need l-arginine for a deficiency could lead to infertility.


L-arginine is commonly sold as a health supplement claimed to be capable of improving vascular health and enhancing sexual function in men.

Source :-Amino acids are the major components of protein. Animal and plant products contain several amino acids, including arginine. Some of these sources are meats, milk, and eggs.The physiologically active form, L-arginine, is the natural product obtained by hydrolysis of proteins. Because L-arginine can be synthesized endogenously from Lcitrulline, it is classified as nonessential amino acid in adults. However, in children and in certain conditions (eg, trauma, infection), L-arginine synthesis may become compromised and then may be considered "semi-essential.

Uses of L-Arginine

L-arginine has been beneficial in several cardiovascular diseases (eg, congestive heart failure, peripheral artery disease, angina, hypertension, hyperlipidemia) and type 2 diabetes. It plays an important role in healing and increases nitric oxide concentrations.

L-arginine is essential for young children and for those with certain rare genetic disorders in which synthesis of the amino acid is impaired. Some stress conditions that put an increased demand on the body for the synthesis of L-arginine include trauma (including surgical trauma), sepsis and burns. Under these conditions, L-arginine becomes essential, and it is then very important to ensure adequate dietary intake of the amino acid to meet the increased physiological demands created by these situations.

Side Effects of L-Arginine

L-arginine has few reported side effects. Nausea and diarrhea have been reported infrequently. Parenteral administration at high doses has caused metabolic acidosis or electrolyte alterations.


2 to 30 grams. Each person has biochemical individuality, and significantly differing needs for amino acid supplements. When supplementing arginine orally, some researchers recommend taking the supplements for two months, then discontinuing for two months before starting a new "cycle." A Take a small dosage for one week, note the benefits and the side effects, and increase or decrease the dosage until the benefits are maximized and the side effects minimized.


Parenteral administration of L-arginine in high doses has caused metabolic acidosis including elevated potassium levels due to effects on intra and extracellular potassium balance. Oral administration of L-arginine in humans has not caused any major adverse effects. L-arginine may exacerbate sickle cell crisis. Doses up to 30 g/day are well tolerated, with infrequent reports of nausea and diarrhea. No adverse effects were reported with 9 g/day L-arginine over 6 months. Arginine may trigger onset of herpes infection, although there is no solid evidence to confirm this.

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